Small Intestinal Mucosal Biopsies for Case-Finding in Celiac Disease

A case of small-intestinal mucosal atrophy.

A patient is described with a severe malabsorption syndrome which failed to respond to a gluten-free diet. Although subtotal villous atrophy was present in the jejunal mucosa, histological features of subepithelial fibrosis and apparently normal enterocytes were not suggestive of coeliac disease. The findings of decreased mucosal thickness, of a normal mitotic rate in the crypt cell population,...

Celiac disease: how many biopsies for diagnosis?

Small-intestinal histopathology and mortality risk in celiac disease.

CONTEXT Studies of mortality in celiac disease have not taken small-intestinal pathology into account. OBJECTIVE To examine mortality in celiac disease according to small-intestinal histopathology. DESIGN, SETTING, AND PATIENTS Retrospective cohort study. We collected data from duodenal/jejunal biopsies taken between July 1969 and February 2008 on celiac disease (Marsh stage 3: villous atro...

Mucosal Expression of Claudins in Celiac Disease

Mucosal tissue transglutaminase expression in celiac disease

Tissue transglutaminase (tTG) plays an important role in celiac disease pathogenesis and antibodies to tTG are a diagnostic marker of gluten-sensitive enteropathy. The aim of this study was to investigate the localization of tTG in the duodenal mucosa in control tissues and in different histological stages of celiac disease by using a commercial and a novel set of anti-tTG monoclonal antibodies...